Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5
Identifieur interne : 000164 ( France/Analysis ); précédent : 000163; suivant : 000165Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5
Auteurs : Prisca Exertier [France] ; Sophie Javerzat [France] ; Baigang Wang [Allemagne] ; Mélanie Franco [France] ; John Herbert [Royaume-Uni] ; Natalia Platonova [France] ; Marie Winandy [Belgique] ; Nadège Pujol [France] ; Olivier Nivelles [Belgique] ; Sandra Ormenese [Belgique] ; Virginie Godard [France] ; Jürgen Becker [Allemagne] ; Roy Bicknell [Royaume-Uni] ; Raphael Pineau [France] ; Jörg Wilting [Allemagne] ; Andreas Bikfalvi [France] ; Martin Hagedorn [France]Source :
- Oncotarget [ 1949-2553 ] ; 2013.
Abstract
Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis, migration and intracellular transport through interaction with microtubules. Small molecule inhibitors of the mitotic kinesin KiF11/Eg5 are a promising new class of anti-neoplastic agents currently evaluated in clinical cancer trials for solid tumors and hematological malignancies. Here we report induction of Eg5 and four other mitotic kinesins including KIF20A/Mklp2 upon stimulation of in
Url:
PubMed: 24327603
PubMed Central: 3926828
Affiliations:
- Allemagne, Belgique, France, Royaume-Uni
- Angleterre, Aquitaine, Aquitaine-Limousin-Poitou-Charentes, Midlands de l'Ouest, Nouvelle-Aquitaine, Province de Liège, Région wallonne
- Birmingham, Bordeaux, Liège, Talence
- Université de Liège
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PMC:3926828Le document en format XML
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Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation></author><author><name sortKey="Javerzat, Sophie" sort="Javerzat, Sophie" uniqKey="Javerzat S" first="Sophie" last="Javerzat">Sophie Javerzat</name><affiliation wicri:level="1"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Baigang" sort="Wang, Baigang" uniqKey="Wang B" first="Baigang" last="Wang">Baigang Wang</name><affiliation wicri:level="1"><nlm:aff id="A3"> Ruhr-Universität Bochum, Medizinische Fakultät; Abt. f. Anatomie und Embryologie, D-44780 Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Ruhr-Universität Bochum, Medizinische Fakultät; Abt. f. Anatomie und Embryologie, D-44780 Bochum</wicri:regionArea><wicri:noRegion>44780 Bochum</wicri:noRegion><wicri:noRegion>44780 Bochum</wicri:noRegion><wicri:noRegion>D-44780 Bochum</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A8"> Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Georg-August-Universität Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Georg-August-Universität Goettingen</wicri:regionArea><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Franco, Melanie" sort="Franco, Melanie" uniqKey="Franco M" first="Mélanie" last="Franco">Mélanie Franco</name><affiliation wicri:level="1"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation></author><author><name sortKey="Herbert, John" sort="Herbert, John" uniqKey="Herbert J" first="John" last="Herbert">John Herbert</name><affiliation wicri:level="3"><nlm:aff id="A4"> Molecular Angiogenesis Group, Institute of Biomedical Research, Univ Birmingham, Medical School, Edgbaston, Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Molecular Angiogenesis Group, Institute of Biomedical Research, Univ Birmingham, Medical School, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Platonova, Natalia" sort="Platonova, Natalia" uniqKey="Platonova N" first="Natalia" last="Platonova">Natalia Platonova</name><affiliation wicri:level="3"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation></author><author><name sortKey="Winandy, Marie" sort="Winandy, Marie" uniqKey="Winandy M" first="Marie" last="Winandy">Marie Winandy</name><affiliation wicri:level="4"><nlm:aff id="A5"> GIGA, Zebrafish Facility, Tour B34, Université de Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> GIGA, Zebrafish Facility, Tour B34, Université de Liège</wicri:regionArea><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author><author><name sortKey="Pujol, Nadege" sort="Pujol, Nadege" uniqKey="Pujol N" first="Nadège" last="Pujol">Nadège Pujol</name><affiliation wicri:level="3"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation></author><author><name sortKey="Nivelles, Olivier" sort="Nivelles, Olivier" uniqKey="Nivelles O" first="Olivier" last="Nivelles">Olivier Nivelles</name><affiliation wicri:level="4"><nlm:aff id="A6"> GIGA, Unité de Biologie Moléculaire et Génie Génétique, Tour B34, Université de Liège, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> GIGA, Unité de Biologie Moléculaire et Génie Génétique, Tour B34, Université de Liège</wicri:regionArea><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author><author><name sortKey="Ormenese, Sandra" sort="Ormenese, Sandra" uniqKey="Ormenese S" first="Sandra" last="Ormenese">Sandra Ormenese</name><affiliation wicri:level="4"><nlm:aff id="A7"> GIGA, Imaging and Flow Cytometry Facility, Tour B34, Université de Liege, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea> GIGA, Imaging and Flow Cytometry Facility, Tour B34, Université de Liege</wicri:regionArea><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author><author><name sortKey="Godard, Virginie" sort="Godard, Virginie" uniqKey="Godard V" first="Virginie" last="Godard">Virginie Godard</name><affiliation wicri:level="3"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation></author><author><name sortKey="Becker, Jurgen" sort="Becker, Jurgen" uniqKey="Becker J" first="Jürgen" last="Becker">Jürgen Becker</name><affiliation wicri:level="1"><nlm:aff id="A8"> Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Georg-August-Universität Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Georg-August-Universität Goettingen</wicri:regionArea><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Bicknell, Roy" sort="Bicknell, Roy" uniqKey="Bicknell R" first="Roy" last="Bicknell">Roy Bicknell</name><affiliation wicri:level="3"><nlm:aff id="A4"> Molecular Angiogenesis Group, Institute of Biomedical Research, Univ Birmingham, Medical School, Edgbaston, Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Molecular Angiogenesis Group, Institute of Biomedical Research, Univ Birmingham, Medical School, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Pineau, Raphael" sort="Pineau, Raphael" uniqKey="Pineau R" first="Raphael" last="Pineau">Raphael Pineau</name><affiliation wicri:level="3"><nlm:aff id="A9"> Animalerie mutualisée, University of Bordeaux I, Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Animalerie mutualisée, University of Bordeaux I, Talence</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Wilting, Jorg" sort="Wilting, Jorg" uniqKey="Wilting J" first="Jörg" last="Wilting">Jörg Wilting</name><affiliation wicri:level="1"><nlm:aff id="A8"> Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Georg-August-Universität Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Zentrum Anatomie, Abteilung Anatomie und Zellbiologie, Georg-August-Universität Goettingen</wicri:regionArea><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion><wicri:noRegion>Georg-August-Universität Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Bikfalvi, Andreas" sort="Bikfalvi, Andreas" uniqKey="Bikfalvi A" first="Andreas" last="Bikfalvi">Andreas Bikfalvi</name><affiliation wicri:level="1"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation></author><author><name sortKey="Hagedorn, Martin" sort="Hagedorn, Martin" uniqKey="Hagedorn M" first="Martin" last="Hagedorn">Martin Hagedorn</name><affiliation wicri:level="1"><nlm:aff id="A1"> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ. Bordeaux, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><wicri:noRegion>33405 Talence</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> INSERM, LAMC, UMR 1029, F-33405 Talence, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, LAMC, UMR 1029, F-33405 Talence</wicri:regionArea><wicri:noRegion>33405 Talence</wicri:noRegion><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis, migration and intracellular transport through interaction with microtubules. Small molecule inhibitors of the mitotic kinesin KiF11/Eg5 are a promising new class of anti-neoplastic agents currently evaluated in clinical cancer trials for solid tumors and hematological malignancies. Here we report induction of Eg5 and four other mitotic kinesins including KIF20A/Mklp2 upon stimulation of in <italic>vivo</italic> angiogenesis with vascular endothelial growth factor-A (VEGF-A). Expression analyses indicate up-regulation of several kinesin-encoding genes predominantly in lymphoblasts and endothelial cells. Chemical blockade of Eg5 inhibits endothelial cell proliferation and migration in <italic>vitro</italic>. Mitosis-independent vascular outgrowth in aortic ring cultures is strongly impaired after Eg5 or Mklp2 protein inhibition. <italic>In vivo</italic>, interfering with KIF11/Eg5 function causes developmental and vascular defects in zebrafish and chick embryos and potent inhibition of tumor angiogenesis in experimental tumor models. Besides blocking tumor cell proliferation, impairing endothelial function is a novel mechanism of action of kinesin inhibitors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name></author><author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neufeld, G" uniqKey="Neufeld G">G Neufeld</name></author><author><name sortKey="Cohen, T" uniqKey="Cohen T">T Cohen</name></author><author><name sortKey="Gengrinovitch, S" uniqKey="Gengrinovitch S">S Gengrinovitch</name></author><author><name sortKey="Poltorak, Z" uniqKey="Poltorak Z">Z Poltorak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanne, Jh" uniqKey="Tanne J">JH Tanne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilting, J" uniqKey="Wilting J">J 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uniqKey="Toda M">M Toda</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Aquitaine-Limousin-Poitou-Charentes</li><li>Midlands de l'Ouest</li><li>Nouvelle-Aquitaine</li><li>Province de Liège</li><li>Région wallonne</li></region><settlement><li>Birmingham</li><li>Bordeaux</li><li>Liège</li><li>Talence</li></settlement><orgName><li>Université de Liège</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Exertier, Prisca" sort="Exertier, Prisca" uniqKey="Exertier P" first="Prisca" last="Exertier">Prisca Exertier</name></noRegion><name sortKey="Bikfalvi, Andreas" sort="Bikfalvi, Andreas" uniqKey="Bikfalvi A" first="Andreas" last="Bikfalvi">Andreas Bikfalvi</name><name sortKey="Bikfalvi, Andreas" sort="Bikfalvi, Andreas" uniqKey="Bikfalvi A" first="Andreas" last="Bikfalvi">Andreas Bikfalvi</name><name sortKey="Exertier, Prisca" sort="Exertier, Prisca" uniqKey="Exertier P" first="Prisca" last="Exertier">Prisca Exertier</name><name sortKey="Franco, Melanie" sort="Franco, Melanie" uniqKey="Franco M" first="Mélanie" last="Franco">Mélanie Franco</name><name sortKey="Franco, Melanie" sort="Franco, Melanie" uniqKey="Franco M" first="Mélanie" last="Franco">Mélanie Franco</name><name sortKey="Godard, Virginie" sort="Godard, Virginie" uniqKey="Godard V" first="Virginie" last="Godard">Virginie Godard</name><name sortKey="Godard, Virginie" sort="Godard, Virginie" uniqKey="Godard V" first="Virginie" last="Godard">Virginie Godard</name><name sortKey="Hagedorn, Martin" sort="Hagedorn, Martin" uniqKey="Hagedorn M" first="Martin" last="Hagedorn">Martin Hagedorn</name><name sortKey="Hagedorn, Martin" sort="Hagedorn, Martin" uniqKey="Hagedorn M" first="Martin" last="Hagedorn">Martin Hagedorn</name><name sortKey="Javerzat, Sophie" sort="Javerzat, Sophie" uniqKey="Javerzat S" first="Sophie" last="Javerzat">Sophie Javerzat</name><name sortKey="Javerzat, Sophie" sort="Javerzat, Sophie" uniqKey="Javerzat S" first="Sophie" last="Javerzat">Sophie Javerzat</name><name sortKey="Pineau, Raphael" sort="Pineau, Raphael" uniqKey="Pineau R" first="Raphael" last="Pineau">Raphael Pineau</name><name sortKey="Platonova, Natalia" sort="Platonova, Natalia" uniqKey="Platonova N" first="Natalia" last="Platonova">Natalia Platonova</name><name sortKey="Platonova, Natalia" sort="Platonova, Natalia" uniqKey="Platonova N" first="Natalia" last="Platonova">Natalia Platonova</name><name sortKey="Pujol, Nadege" sort="Pujol, Nadege" uniqKey="Pujol N" first="Nadège" last="Pujol">Nadège Pujol</name><name sortKey="Pujol, Nadege" sort="Pujol, Nadege" uniqKey="Pujol N" first="Nadège" last="Pujol">Nadège Pujol</name></country><country name="Allemagne"><noRegion><name sortKey="Wang, Baigang" sort="Wang, Baigang" uniqKey="Wang B" first="Baigang" last="Wang">Baigang Wang</name></noRegion><name sortKey="Becker, Jurgen" sort="Becker, Jurgen" uniqKey="Becker J" first="Jürgen" last="Becker">Jürgen Becker</name><name sortKey="Wang, Baigang" sort="Wang, Baigang" uniqKey="Wang B" first="Baigang" last="Wang">Baigang Wang</name><name sortKey="Wilting, Jorg" sort="Wilting, Jorg" uniqKey="Wilting J" first="Jörg" last="Wilting">Jörg Wilting</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Herbert, John" sort="Herbert, John" uniqKey="Herbert J" first="John" last="Herbert">John Herbert</name></region><name sortKey="Bicknell, Roy" sort="Bicknell, Roy" uniqKey="Bicknell R" first="Roy" last="Bicknell">Roy Bicknell</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Winandy, Marie" sort="Winandy, Marie" uniqKey="Winandy M" first="Marie" last="Winandy">Marie Winandy</name></region><name sortKey="Nivelles, Olivier" sort="Nivelles, Olivier" uniqKey="Nivelles O" first="Olivier" last="Nivelles">Olivier Nivelles</name><name sortKey="Ormenese, Sandra" sort="Ormenese, Sandra" uniqKey="Ormenese S" first="Sandra" last="Ormenese">Sandra Ormenese</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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